Figure 5.

Altered EfnB2 reverse signaling significantly affects lung mechanics. Pulmonary function tests determined that 8-week-old mice with disrupted reverse Efnb2 signaling exhibited a significant increase in elastance (B, P = 0.04) and tissue damping (C, P = 0.0185). Consistent with these findings, a marked decrease in lung compliance (F, P = 0.02) was evident, with a shift down and to the right, and diminished hysteresis of the volume–pressure loops (E, dotted lines) in Efnb2^LacZ/6YFΔV mice compared with WT littermates (E, solid lines), consistent with lungs that demonstrate increased resistance. Airway resistance (A), tissue damping (C), and hysteresivity (D) were similar between the groups.