Figure 1.
Effects of dimethylarginine dimethylaminohydrolase (DDAH) overexpression on pulmonary arterial pressure (PAP) during normoxic and hypoxic ventilation of isolated lungs. (A) Increase of PAP (ΔPAP) during normoxic and hypoxic ventilation was referenced to PAP values at time point 0 (normoxic ventilation). *Significant difference (P < 0.05) between lungs from wild-type mice (WT) and DDAH1-overexpressing mice (DDAH1tg). No significant difference in ΔPAP was evident during the second acute hypoxic ventilation, performed at Minutes 235–245, when related to PAP values at the onset of hypoxic ventilation (235 minutes). Each data point is derived from n = 8–10 lungs per group. (B) PAP during 255 minutes of normoxic ventilation. Each data point is derived from n = 3 lungs per group.