TABLE 3.
SERUM IMMUNOGLOBULIN TITERS AFTER IMMUNIZATION WITH HEAT-KILLED MYCOPLASMA
| Days after Infection | Exposure Group | IgM | IgG1 | IgG2a |
|---|---|---|---|---|
| 7 |
Ctsl+/+ + M.p. |
2.00 ± 0.26 |
3.31 ± 0.53 |
2.3 ± 0.53 |
|
Ctsl−/− + M.p. |
0.87 ± 0.43 |
2.3 ± 0.53 |
2.3 ± 0.72 |
|
| 14 |
Ctsl+/+ + M.p. |
1.20 ± 0.42 |
2.48 ± 0.84 |
2.05 ± 0.38 |
| Ctsl−/− + M.p. | 0.65 ± 0.38 | 2.66 ± 0.57 | 2.66 ± 0.96 |
Definition of abbreviations: Ctsl, cathepsin L; M.p., M. pulmonis.
IgA and IgE are not shown, and were undetectable in any sample. Values represent means ± SEMs (n = 3–5). No significant differences were evident between titers in infected Ctsl+/+ and Ctsl−/− serum (according to t tests) at any time point. No M.p.-specific antibodies were detected in PBS-injected control Ctsl+/+ or Ctsl−/− mice.