TABLE 2.
RELATIVE QUANTIFICATION OF THE Tc-99m ALBUMIN NANOCOLLOID IN DIFFERENT REGIONS OF INTEREST OF PIG LUNGS
| Region of interest | Ctrl B2 | B1 | B2 | B3 | B4 |
|---|---|---|---|---|---|
| C/P ratio (left) |
1.36 |
1.27 |
1.45 |
0.87 |
1.27 |
| C/P ratio (right) |
1.50 |
2.33 |
1.67 |
0.42 |
0.77 |
| C/P ratio (lateral) |
1.03 |
ND |
ND |
ND |
ND |
| Diaphragmatic (%) |
27 |
26 |
33 |
33 |
20 |
| Middle (%) |
43 |
29 |
28 |
29 |
38 |
| Apical (%) |
16 |
10 |
9 |
13 |
16 |
| Trachea and main bronchi (%) | 14 | 35 | 30 | 25 | 26 |
Definition of abbreviations: C, central; Ctrl, control; ND, not determined; P, peripheral; Tc-99m, technetium-99m.
The normalized central/peripheral count ratios were calculated considering the perfusion scan as lung volume. Relative percentages of the Tc-99m radiopharmaceutical in different areas of pig lungs were also determined. B1–B4 indicate animals belonging to the cohort treated with Tc-99m albumin nanocolloid receptor-targeted nanoparticles, whereas Ctrl B2 is a control pig.