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. 2013 Sep;49(3):403–409. doi: 10.1165/rcmb.2013-0100OC

Figure 2.

Figure 2.

Response of PAH PAECs to ataluren is dose dependent. PAECs with the BMPR2 R321X mutation were treated for 24 hours with a range of ataluren concentrations as indicated, followed by the addition of BMP9 for 4 hours. (A) miR-27a normalized to RNU48. Induction of miR-27a is dose dependent to 20 μM, then plateaus. (B) ID1 mRNA normalized to GAPDH, as a readout of canonical BMP signaling. R321X shows no deficit in ID1 induction and no change with ataluren treatment. Means (±SEM) of nine replicates are shown.