Fig. 2.

mbd2/3(RNAi) Leads to the disruption of various differentiated tissues during regeneration. (A) mbd2/3(RNAi) effect at 7 days of regeneration showing defects in pharynx (white asterisk) and eye (white arrows) formation. (B)–(F) mbd2/3(RNAi) affects the formation of the eyes (B), pharynx (C), anterior and posterior gut branches (black arrow heads) (D) and (E), brain ganglia (F) and (G); yellow arrows in (G), cells in and around the CNS (H) and secretory gland cells around the pharynx (I) during regeneration. However, the VNCs (G), blue arrows), cilia and secretory cell types are formed during regeneration. White dashed lines represent the boundary between the old and new tissue. Immunostaining was performed in (B), (E), (G) and (J), in situ hybridisation in (C), (D), (F), (H) and (I). 3C11: anti-SYNORF-1.