Fig. 3.

LPS decreases the number of newborn neurons and astrocytes on cells born during the inflammatory response. (A, C) Confocal microscope analysis (BrdU-positive cells (red), NeuN-positive cells (green)) revealed no changes in the number of newborn neurons in cells born prior to an inflammatory response. However, if cells were born during a period of inflammation, there was a significant decrease in the number of newborn neurons. (B, C) Confocal microscope analysis (BrdU-positive cells (red), S100β-positive cells (blue)) revealed no changes in the number of newborn astrocytes in cells born prior to an inflammatory response. However, if cells were born during a period of inflammation, there was a significant decrease in the number of newborn astrocytes. Group means ± SEM. Scale bar = 50 μm. ^∗P < 0.05, ^∗∗P < 0.01. Arrows pointing to the right indicate BrdU-positive neuron and arrows pointing to the left indicate BrdU-positive astrocyte. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)