Fig. 5.

LPS reduces the survival of newborn cells specifically in the dorsal hippocampus. (A) The area of the dorsal and ventral granule cell layer (GCL) was similar in LPS-exposed pups compared to saline control at P60. (B–D) Survival of BrdU-positive cells, labeled at P11, 48 h after LPS, was significantly reduced in the dorsal hippocampus at P60 compared to sham animals. (B) There was no effect by neonatal LPS on survival of BrdU labeled cells in the ventral hippocampus at P60. Group means ± SEM. ^∗P < 0.05, ^∗∗P < 0.01.