Table 1.

Association of PD with HLA Alleles

HLA Alleles	Allele Frequency in NGRC		NGRC		Replication		Meta-Analysis
	PD	Control	OR	p	OR	p	OR	p
B∗07:02	0.15	0.13	1.20	8 × 10−3	1.31	0.01	1.23	3 × 10−4
B∗40:01	0.05	0.06	0.79	0.02	0.71	0.03	0.76	2 × 10−3
C∗03:04	0.07	0.09	0.76	2 × 10−3	0.63	6 × 10−4	0.72	8 × 10−6
C∗07:02	0.16	0.14	1.22	3 × 10−3	1.25	0.03	1.23	2 × 10−4
DRB1∗04:04	0.03	0.05	0.64	5 × 10−4	0.67	0.03	0.65	4 × 10−5
DRB1∗15:01	0.16	0.13	1.26	9 × 10−4	1.26	0.02	1.26	6 × 10−5
DRB4∗01	0.26	0.29	0.85	3 × 10−3	0.80	4 × 10−3	0.83	4 × 10−5
DRB5∗01	0.16	0.14	1.25	8 × 10−4	1.25	0.03	1.25	5 × 10−5
DQA1∗01:02	0.22	0.20	1.15	0.02	1.22	0.02	1.17	1 × 10−3
DQA1∗03:01	0.15	0.19	0.77	1 × 10−4	0.76	3 × 10−3	0.77	1 × 10−6
DQB1∗03:02	0.09	0.11	0.75	3 × 10−4	0.73	7 × 10−3	0.74	7 × 10−6
DQB1∗06:02	0.16	0.13	1.26	7 × 10−4	1.27	0.02	1.26	4 × 10−5

Class I and class II HLA alleles with frequency ≥ 0.01 were tested in NGRC. Fourteen alleles with p < 0.05 for association with PD were tested for replication. Twelve that replicated are shown. Tests were conducted under the additive model and adjusted for principal components 1 and 2. p values (including those for the replication data set) are two sided and uncorrected for multiple testing. The Bonferroni-corrected threshold for 14 tests is p = 3 × 10⁻³.