Table 1.

Effect of IFZN on carrageenan, dextran, histamine and serotonin induced rat paw oedema.

Treatment	Dose mg/kg BW (p.o.)	Increase in paw oedema in milliliters (mean + SEM)
		Carrageenan		Dextran		Histamine		Serotonin
		1 h	3 h	1 h	3 h	1 h	3 h	1 h	3 h
Control	5 (ml/kg)	0.90 ± 0.02	0.94 ± 0.03	0.92 ± 0.02	0.98 ± 0.05	0.94 ± 0.01	1.02 ± 0.05	0.95 ± 0.01	0.99 ± 0.03
Indomethacin	10	0.36 ± 0.03⁎	0.25 ± 0.03⁎	0.41 ± 0.02⁎	0.25 ± 0.04⁎	0.36 ± 0.01⁎	0.25 ± 0.01⁎	0.42 ± 0.01⁎	0.25 ± 0.01⁎
IFZN I	10	0.57 ± 0.02⁎	0.43 ± 0.05⁎	0.62 ± 0.01⁎	0.46 ± 0.02∗	0.53 ± 0.01⁎	0.48 ± 0.02⁎	0.63 ± 0.01⁎	0.48 ± 0.02⁎
IFZN II	20	0.50 ± 0.02⁎	0.40 ± 0.04⁎	0.51 ± 0.01⁎	0.43 ± 0.03⁎	0.50 ± 0.01⁎	0.48 ± 0.03⁎	0.56 ± 0.02⁎	0.46 ± 0.03⁎
IFZN III	30	0.47 ± 0.01⁎	0.38 ± 0.04⁎	0.46 ± 0.01⁎	0.41 ± 0.02⁎	0.44 ± 0.01⁎	0.42 ± 0.02⁎	0.52 ± 0.03⁎	0.44 ± 0.04⁎

Values reported as mean ± SEM (n = 6). The data were analyzed by one way ANOVA followed by Dunnett’s test.

^⁎P < 0.05 as compared with the control group. IFZN (cyclopeptide alkaloid fraction of leaves of Ziziphus nummularia).