Table 2.
Effect of IFZN on cotton pellet induced granuloma and carrageenan induced peritonitis in mice.
| Treatment | Dose mg/kg (p.o.) | Weight of cotton pellet mg (moist) | Percentage inhibition | Weight of cotton pellet mg (Dried) | Percentage inhibition | Leukocytes (103 cmm) |
|---|---|---|---|---|---|---|
| Control | 5 (ml/kg) | 177.33 ± 5.93 | – | 69.42 ± 2.33 | 4.32 ± 0.21 | |
| Indomethacin | 10 | 76.00 ± 2.88⁎ | 57.06 | 23.32 ± 1.67⁎ | 66.18 | 2.10 ± 0.07⁎ |
| IFZN I | 10 | 132.50 ± 1.61⁎ | 25.14 | 32.50 ± 1.61⁎ | 52.90 | 2.88 ± 0.09⁎ |
| IFZN II | 20 | 120.33 ± 2.35⁎ | 32.02 | 23.50 ± 0.89⁎⁎ | 65.94 | 2.73 ± 0.11⁎ |
| IFZN III | 30 | 96.00 ± 2.07⁎ | 45.76 | 19.00 ± 1.37⁎⁎ | 72.46 | 2.65 ± 0.06⁎ |
Values reported as mean ± SEM (n = 6). The data were analyzed by one way ANOVA followed by the Dunnett’s test.
⁎
P < 0.05.
⁎⁎
P < 0.01 as compared with the control group. IFZN (cyclopeptide alkaloid fraction of leaves of Ziziphus nummularia).