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. 2013 Jul 24;33(11):1778–1788. doi: 10.1038/jcbfm.2013.126

Figure 6.

Figure 6

Differentiation patterns of endogenous and grafted neural precursor cells (NPCs) are not affected by TAT-heat-shock protein 70 (Hsp70) treatment. (A) Quantitative differentiation analysis (n=12 per condition) of green fluorescence protein positive (GFP+) transplanted NPCs on day 84 within the ischemic hemisphere of mice that had been treated with either TAT-Hsp70 or TAT-HA before. Representative photos were taken on day 84 within the ischemic striatum of animals that had received a combinational therapy consisting of both TAT-Hsp70 and NPCs. (B) Quantitative analysis (n=11 to 12 per condition) of 5-bromo-2-desoxyuridine positive (BrdU+) endogenous cells on day 84 within the ischemic hemisphere. Animals had been treated with either TAT-Hsp70 or TAT-HA (during reperfusion plus day 14) followed by additional infusion (day 28) of either NPCs or NaCl as control. (C) Quantitative differentiation analysis of BrdU+ cells from (B) within the ischemic hemisphere on day 84 poststroke. (D) Analysis of growth factor contents in ischemic hemispheres (n=5 per condition) on day 84 from animals that had been treated as described in (B). *Significantly different from controls, P<0.05. Scale bars, 20 μm. GFAP, glial fibrillary acidic protein.