Figure 1.

The effect of alteplase on cerebral blood flow (CBF), percentage weight loss, and neuroscore after cerebral ischemia. (A) Cerebral blood flow was continuously monitored during the first 60 minutes of reperfusion while treatments were administered. Reperfused CBF never recovered to pre-middle cerebral artery occlusion (MCAO) CBF levels. There was no significant effect of treatment on reperfused CBF. (B) The percentage weight loss for each animal was assessed 24 hours after MCAO onset. There was no significant effect of treatment (horizontal bar indicates the mean of each group). (C) Total neuroscore was calculated through a battery of six sub-tests 24 hours after MCAO onset. There were no significant effects of treatment group on total neuroscore (horizontal bar indicates the median of each group).