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. 2013 Nov 12;7:177. doi: 10.3389/fncir.2013.00177

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Copyright © 2013 Rah, Bas, Colonell, Mishchenko, Karsh, Fetter, Myers, Chklovskii, Svoboda, Harris and Isaac.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LSAT shows that TC synapses are concentrated on proximal basal dendrites of L5 pyramidal neurons. (A) Three dimensional Scholl analysis of dendritic structure of reconstructed L5 pyramidal neurons, and (B) Number of TC synapses as a function of path distance from center of soma. (C) Average density of TC synapses from all annotated neurons (aligned relative to cell bodies; false color scale) represented on top of all dendrites from all the traced neurons (white lines, superimposed; scale bar 100 μm). (D,E) Spatial distribution of the functional TC input mapped using sCRACM (Petreanu et al., 2009) (D), false color scale; reduced to 80% of size to compensate for the tissue shrinkage during LSAT processing) and distribution of TC synapses detected by LSAT (E) average from all annotated neurons aligned relative to pia; scale bar 100 μm). (F) Overlay of TC laminar distribution measured by sCRACM and LSAT.