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LHVS reduces cerebral edema in the ipsilateral cortex 24 h after traumatic brain injury (TBI). Brain water content was significantly higher in the TBI and TBI + vehicle groups than in the sham group. Pretreatment with LHVS significantly attenuated brain water content in the ipsilateral cortex compared with vehicle pretreatment. Data are presented as mean ± SEM. **P < 0.01, ***P < 0.001 versus sham group (n = 5); # P < 0.05 versus TBI + vehicle group.
