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. 2013 Nov 12;3:277. doi: 10.3389/fonc.2013.00277

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Copyright © 2013 Pihan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chromoanagenesis in cancer. Complex structural chromosome rearrangements in cancer, involve stepwise or punctual chromosome restructuring. It includes stepwise classic intra or inter-chromosomal break-fusion-bridge cycles (A); chromothripsis (B), which are punctual localized highly complex chromosome fragmentation (1) and rejoining (2) events, and chromoplexy (C), in which complex linked translocation events involving multiple chromosomes presumably occur simultaneously. 1 through 6 (black typeface) and 1 through 5 (orange typeface) represent two such linked “chained” events.