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The diagnostic accuracy of GPC3S was performed by ROC curves.
The GPC3S was over 3.5µg/L in 48.8% of patients with AFP<400µg/L. The sensitivity and specificity in all, AFP greater or equal to 400µg/L and AFP negative HCC patients were 54.6%, 75%, 54.6% and 80%, 80%, 76%, respectively. The positive predictive value and negative predictive value were 83.3%, 60%, 77.8% and 43.2%, 86.4%, 46.3%, respectively
