Skip to main content
. 2013 Aug 6;4(9):1388–1398. doi: 10.18632/oncotarget.1239

Figure 5. miR-27a* expression reduces tumor growth in vivo and direct intratumoral injection reduces tumor growth.

Figure 5

(A) Orthotopic xenografts of 22B cells expressing miR-27a* (pSuper-27a*) show reduced growth compared to control vector (pSuper); * at day 16 indicates point at which differences in tumor volume became statistically significant, p<0.05; (B) Tumor growth curve of 22B cells with inducible miR-27a* expression. One group of mice was treated with doxycycline (Doxy) to induce miR-27a* expression after tumors developed (day 0). Tumor volumes were significantly decreased in mice who received doxycycline; * marks day 18 when differences in tumor volumes became statistically significant, p<0.05; (C) Scatter plot depicting a statistically significant increase in miR-27a* RNA collected from murine tumor tissue in the doxycycline group compared to the non-doxycycline group, p<0.01; (D) Direct intratumoral injection significantly reduces growth of 17B tumors in mice treated with pSuper-27a* compared to control and pSuper; * marks day 18 when differences in tumor volumes became statistically significant (p<0.05) for pSuper-27a* compared to the control groups.