Table 2. Genes and aging-associated intracellular signaling pathways, that are activated by the study drugs in Homo sapiens.

Drug	Genes*	Longevity pathway IDs**
Rapamycin	GMNN RORC SMAD3 CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2 DRD2 NR3C1 OPRM1 ESR1 carbonic anhydrase II/CA II PTGS2 ACHE MC4R ESR2 PTSG1 ADRB2 DRD3 SLC6A3 CHRM1 GSK3B NET ABCB1 CHRM3 FLT1 DRD4 CHRM2 CHEK1 ADRB3 ADRB1 CCR5 CCR2 MAOA HRH1 MAPKAPK2 MC3R TBXAS1 MC5R NPY1R CHRM4 ROCK2 PLK1 ACHE AVPR1A NOS2 CHRM5 AKR1B1 MAP2K1 MAP2K1 CHEK2 CYSLTR1 HRH2 NPY2R CCR4 PTPRC MAPKAPK5 CTSG USP1 CYP2A6 ALOX15 ACE MAPKAPK3 MELK PAK4 CALCR VIPR1 LTC4S CSK BCHE SGK1 HIPK2 MYLK HIPK3 SLCO1B1 MAPK15 ROCK2 AKT1 PDCD4	Circadian rhythm Caffeine metabolism Hippo signaling pathway Hedgehog signaling pathway TGF-beta signaling pathway PI3K-Akt signaling pathway MAPK signaling pathway Natural killer cell mediated cytotoxicity mTOR signaling pathway Jak-STAT signaling pathway
Wortmannin	GMNN POLI MAPT NFE2L2 SMAD3 PIN1 VDR IMPA1 GLS RGS4 APOBEC3G WRN GSK3B ERG RECQL CHEK1 MAPKAPK2 ROCK2 PLK1 ACHE MAP2K1 CHEK2 MAPKAPK5 MAPKAPK3 MELK PAK4 CSK BCHE SGK1 HSP90AA1 PLK3 HIPK2 MYLK PLK2 HIPK3 MAPK15 MYLK ROCK2	MAPK signaling pathway TGF-beta signaling pathway Hippo signaling pathway PI3K-Akt signaling pathway Hedgehog signaling pathway Natural killer cell mediated cytotoxicity
PDTC	GMNN ATAD5 POLI MAPT CBX1 NFE2L2 RORC TP53 TXNRD1 CYP3A4 LMNA SMN2 CYP2D6 CYP2C9 VDR CYP2C19 CYP1A2 NPSR1 APOBEC3F RGS4 APOBEC3G carbonic anhydrase II/CA II ALOX15 CHRM1 NFKB1 PMP22 MPHOSPH8 RELA	MAPK signaling pathway Circadian rhythm PI3K-Akt signaling pathway Caffeine metabolism
1400W	FTL CYP3A4 SMN2 CYP2D6 CYP2C9 CYP2C19 CYP1A2 POLK CHRM1 NOS2 NFKB1 NOS2	Caffeine metabolism PI3K-Akt signaling pathway MAPK signaling pathway