Fig. 3.

Kaplan-Meier estimated of overall survival shown for mice treated with lapatinib alone or in combination with radiation or doxorubicin. Survival data are shown for mice treated with radiation (a) or doxorubicin (b) alone or in combination with direct or delayed with lapatinib. Treatment groups were compared with age-matched controls. *indicates significant differences between treated mice and age matched control groups (p < 0.05; Mann–Whitney U-test)