Fig. 7.

Histological changes in the myocardium and blood vessels at 40 weeks after treatment with irradiation or doxorubicin alone or in combination with lapatinib. H&E sections of the heart of mice that survived treatment with irradiation alone or in combination with lapatinib. Blood vessel and myocardium were scored for cardiac events at 40 weeks after treatment. Each symbol represents the score of one mouse (minimal five mice per group). a Age-matched control heart. b Dilated capillaries (open arrow) and edema in the stroma (dark arrow) of an irradiated heart. c Hyaline-like degeneration of the coronary arterioles (open arrows). d Atrophy of the myocardium (small, misshapen myocytes, and separated from each other, open arrows). (e) Degeneration of the myocardium. f Focal fibrosis (open arrows) and degeneration of endocardium