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Cardiac function (EF, ESV, and PFR) measured by gated SPECT at 40 weeks after treatment with irradiation or doxorubicin alone or in combination with lapatinib or sham treatment. Values represent mean ± SEM (8–14 mice in each treatment group), *p < 0.05 compared to age-matched untreated controls. Ctrl control; Lap lapatinib; DOX doxorubicin; DOX+Lap doxorubicin combined with lapatinib; IR irradiation; IR + lap irradiation combined with lapatinib
