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. 2013 Oct 4;20(12):1615–1630. doi: 10.1038/cdd.2013.138

Figure 1.

Figure 1

Reactivity of HNE. Here are represented the potential reactions of HNE on the hydroxyl, carbonyl and double bond groups. HNE is biotransformed, but it can also react with proteins according to the Michael addition and the Schiff base formation and DNA by epoxidation