. Author manuscript; available in PMC: 2013 Nov 12.

Published in final edited form as: Nat Rev Rheumatol. 2010 Jun 29;6(8):10.1038/nrrheum.2010.102. doi: 10.1038/nrrheum.2010.102

Table 1.

Vascular changes in SSc^*

Protein	SSc patients	Fli1-knockout mice
*Cell–cell junction*
VE-cadherin	Decreased	Decreased
PECAM1	Decreased	Decreased
*BM–ECM*
Type IV collagen	Decreased	Decreased
MMP9	Increased	Increased
*Pericyte marker*
α-SMA	Decreased	Decreased
RGS5	Increased	ND
S1P1 receptor	ND	Decreased

The table compares vascular changes in the skin of SSc patients and mice with an endothelial-specific conditional knockout of Fli1. Abbreviations: α-SMA, α smooth muscle actin; MMP, matrix metalloproteinase; ND, not determined; PECAM1, platelet endothelial cell adhesion molecule 1; RGS5, regulator of G protein signaling 5; S1P1 receptor, sphingosine 1-phosphate receptor 1; SSc, systemic sclerosis; VE-cadherin, vascular endothelial cadherin.