Table 1.
Protein | SSc patients | Fli1-knockout mice |
---|---|---|
Cell–cell junction | ||
VE-cadherin | Decreased | Decreased |
PECAM1 | Decreased | Decreased |
BM–ECM | ||
Type IV collagen | Decreased | Decreased |
MMP9 | Increased | Increased |
Pericyte marker | ||
α-SMA | Decreased | Decreased |
RGS5 | Increased | ND |
S1P1 receptor | ND | Decreased |
The table compares vascular changes in the skin of SSc patients and mice with an endothelial-specific conditional knockout of Fli1. Abbreviations: α-SMA, α smooth muscle actin; MMP, matrix metalloproteinase; ND, not determined; PECAM1, platelet endothelial cell adhesion molecule 1; RGS5, regulator of G protein signaling 5; S1P1 receptor, sphingosine 1-phosphate receptor 1; SSc, systemic sclerosis; VE-cadherin, vascular endothelial cadherin.