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Proposed model showing the role of TBX2 in conferring drug resistance to DNA-damaging agents. TBX2 appears to be required for the activation of CHK2 and/or its maintenance ensuring the phosphorylation of p53 by CHK2 and hence its stability and transcriptional activity. Active p53 leads to the upregulation of p21 that triggers an S-phase arrest, DNA repair and cell survival
