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Effect of LHX6 on its downstream genes in cancer pathways. (a) Ectopic expression of LHX6 enhanced the expression of p21 and p53, and decreased the expression of Bcl-2, cyclinD1, c-myc, CD44, and MMP7. (b) Expression of p21 and p53 decreased, whereas the expression of Bcl-2, cyclinD1, c-myc, CD44, and MMP7 increased in HBE cells with knockdown of LHX6. (c) Schematic diagram for the mechanisms of LHX6 as a tumour suppressor
