Figure 5.

5D10 treatment deceases serum pNfH levels and improves hindlimb grip strength in SOD1^G93A mice. (a) Quantification of serum pNfH levels in WT or SOD1^G93A mice by MSD analysis, n=3–11 animals/group. (b) Quantification of serum pNfH levels of 5D10 or control antibody treated SOD1^G93A mice (age 100 days) by MSD analysis, n=8–9 animals/group. (c) Correlation analysis of serum pNfH levels and gastrocnemius muscle NMJs. (d) Hindlimb grip strength analysis (in grams) of 5D10 or control antibody treated SOD1^G93A mice (age 100 days), n=8–9 animals/group. Data in a, b and d were shown as mean±S.E.M. P-values in a, b and d were determined by two-tailed unpaired t test, and in c was determined by Pearson correlation analysis