Table 1.

Results of the use of cyproheptadine hydrochroride for in refractory migraine patients prophylaxis

n = 12	Dose of cyproheptadine hydrocride
	4 mg/day (n = 8)	8 mg/day (n = 4)
Gender	male: female 1:7	all female
Average age	34 ± 6	36 ± 5
Frequency of migraine premedication	8.7/month	10.6/month
Frequency of migraine one month after start of treament	1.6/month	1.2/month
Frequency of migraine three month after start of treatment	3.1/month	2.1/month
Adverse reactions	Body weight 28.6%	Body weight 25.0%
	Sleepiness 14.3%	Sleepiness 50.0%