Table 3.
Association of 16 BMI or obesity-associated variants with overweight and obesity among participants of Malmö Diet and Cancer Study
| Gene or nearby gene | SNP (1/2) | Lean versus overweight | Lean versus obese | ||
|---|---|---|---|---|---|
| OR (95 % CI) | P | OR (95 % CI) | P | ||
| FTO | rs9939609 (A/T) | 1.12 (1.08–1.16) | 4.8 × 10−9 | 1.21 (1.14–1.27) | 3.9 × 10−12 |
| MC4R | rs17782313 (C/T) | 1.03 (0.99–1.08) | 0.14 | 1.09 (1.03–1.16) | 0.004 |
| SH2B1 | rs7498665 (G/A) | 1.06 (1.02–1.10) | 0.005 | 1.05 (0.99–1.10) | 0.091 |
| GNPDA2 | rs10938397 (G/A) | 1.07 (1.03–1.11) | 0.001 | 1.10 (1.05–1.16) | 1.4 × 10−4 |
| MTCH2 | rs10838738 (G/A) | 1.00 (0.97–1.04) | 0.86 | 1.03 (0.98–1.09) | 0.25 |
| NEGR1 | rs2815752 (T/C) | 1.04 (1.00–1.08) | 0.051 | 1.09 (1.03–1.14) | 0.002 |
| SFRS10 | rs7647305 (C/T) | 1.06 (1.01–1.11) | 0.021 | 1.04 (0.98–1.11) | 0.20 |
| BCDIN3D/FAIM2 | rs7138803 (A/G) | 1.02 (0.98–1.05) | 0.37 | 1.05 (0.99–1.10) | 0.086 |
| SEC16B/RASAL2 | rs10913469 (C/T) | 1.05 (1.00–1.10) | 0.032 | 1.12 (1.05–1.19) | 3.8 × 10−4 |
| BDNF | rs4923461 (A/G) | 1.06 (1.01–1.11) | 0.012 | 1.08 (1.01–1.15) | 0.026 |
| KCTD15/CHST8 | rs29941 (C/T) | 1.05 (1.02–1.10) | 0.006 | 1.04 (0.99–1.10) | 0.13 |
| TMEM18 | rs6548238 (C/T) | 1.06 (1.01–1.11) | 0.027 | 1.16 (1.08–1.24) | 2.2 × 10−5 |
| NCR3/AIF1/BAT2 | rs2844479 (T/G) | 1.00 (0.96–1.03) | 0.79 | 0.98 (0.93–1.03) | 0.46 |
| PTER locus | rs10508503 (C/T) | 1.00 (0.94–1.06) | 0.92 | 1.01 (0.92–1.10) | 0.84 |
| MAF locus | rs1424233 (A/G) | 1.00 (0.96–1.03) | 0.89 | 0.98 (0.93–1.03) | 0.43 |
| NPC1 | rs1805081 (A/G) | 1.06 (1.02–1.10) | 0.001 | 1.09 (1.04–1.15) | 0.001 |
Adjusted for age and sex
BMI body mass index, SNP single-nucleotide polymorphism, (1/2) 1 refers to risk allele, and 2 refers to other allele; lean: BMI < 25 kg/m2, overweight: 25 kg/m2 ≥ BMI < 30 kg/m2, obese: BMI ≥ 30 kg/m2, OR odds ratio, 95 % CI 95 % confidence interval