Table 2.
Comparison of genotype among patients on the basis of SGA scores
| Genotype | Normal | Mild | Moderate | Severe | Normal versus mild OR (95 % CI), P |
Normal versus moderate OR (95 % CI), P |
Normal versus severe OR (95 % CI), P |
|---|---|---|---|---|---|---|---|
| UCP2 I/D | |||||||
| DD | 47 (60.2 %) | 22 (58.0 %) | 56 (56.0 %) | 24 (58.5 %) | Reference | Reference | Reference |
| ID | 22 (28.2 %) | 8 (21.0 %) | 31 (31.0 %) | 9 (22.0 %) | 0.7 (0.2–2.0), 0.6 | 1.1 (0.6–2.3), 0.6 | 0.8 (0.3–2.0), 0.6 |
| II | 9 (11.5 %) | 8 (21.0 %) | 13 (13.0 %) | 8 (19.5 %) | 1.9 (0.6–5.5), 0.2 | 1.2 (0.4–3.08), 0.7 | 1.7 (0.5–5.0), 0.3 |
| D | 116 (74.3 %) | 52 (68.4 %) | 143 (71.5 %) | 57 (69.5 %) | Reference | Reference | Reference |
| I | 40 (25.7 %) | 24 (31.6 %) | 57 (28.5 %) | 25 (30.5 %) | 1.2 (0.7–2.3), 0.4 | 1.1 (0.69–1.79), 0.7 | 1.2 (0.68–2.2), 0.5 |
| Leptin-2548 G/A | |||||||
| GG | 26 (33.3 %) | 11 (28.9 %) | 38 (38.0 %) | 15 (36.5 %) | Reference | Reference | Reference |
| GA | 31 (39.7 %) | 16 (42.1 %) | 37 (37.0 %) | 15 (36.5 %) | 0.9 (0.4–1.9), 0.8 | 1.1 (0.6–2.0), 0.7 | 0.8 (0.4–1.9), 0.8 |
| AA | 21 (26.9 %) | 11 (28.9 %) | 25 (25.0 %) | 11 (26.8 %) | 0.9 (0.3–2.1), 0.8 | 1.1 (0.5–2.1), 0.8 | 1.0 (0.4–2.3), 1.0 |
| G | 83 (53.4 %) | 38 (50.0 %) | 113 (56.5 %) | 45 (54.8 %) | Reference | Reference | Reference |
| A | 73 (46.7 %) | 38 (50.0 %) | 87 (43.5 %) | 37 (45.2 %) | 1.1 (0.6–1.9), 0.6 | 0.8 (0.5–1.3), 0.6 | 0.9 (0.5–1.5), 0.8 |
| Ghrelin Arg51Gln | |||||||
| GG | 50 (64.1 %) | 22 (57.9 %) | 73 (73.0 %) | 19 (46.3 %) | Reference | Reference | Reference |
| GA | 24 (30.8 %) | 13 (34.2 %) | 23 (23.0 %) | 15 (36.6 %) | 1.2 (0.5–2.6), 0.8 | 0.7 (0.3–1.3), 0.3 | 1.3 (0.5–2.8), 0.5 |
| AA | 4 (5.1 %) | 3 (7.8 %) | 4 (4.0 %) | 7 (17.1 %) | 1.6 (0.3–7.4), 0.6 | 0.8 (0.2–3.2), 0.7 | 3.3 (1.2–13.8), 0.04 |
| G | 124 (79.5 %) | 57 (75.0 %) | 169 (84.5 %) | 53 (64.3 %) | Reference | Reference | Reference |
| A | 32 (29.5 %) | 19 (25.0 %) | 31 (15.5 %) | 29 (35.7 %) | 1.3 (0.7–2.4), 0.5 | 0.6 (0.3–1), 0.1 | 2.1 (1.1–3.8), 0.02* |
| Ghrelin Leu72Met | |||||||
| CC | 63 (80.8 %) | 22 (65.8 %) | 72 (72.0 %) | 21 (51.2 %) | Reference | Reference | Reference |
| CA | 11 (14.1 %) | 10 (26.3 %) | 16 (16.0 %) | 14 (34.1 %) | 2.6 (1.1–6.9), 0.04* | 1.2 (0.5–2.9), 0.5 | 3.8 (1.5–7.6), 0.005* |
| AA | 4 (5.1 %) | 6 (7.9 %) | 12 (12.0 %) | 6 (14.7 %) | 4.2 (1.1–16), 0.03 | 2.6 (0.8–8.5), 0.1 | 4.5 (1.1–10.5), 0.03 |
| C | 137 (87.8 %) | 54 (79.0 %) | 160 (80.0 %) | 56 (68.3 %) | Reference | Reference | Reference |
| A | 19 (12.2 %) | 22 (21.0 %) | 40 (20.0 %) | 26 (31.7 %) | 1.9 (0.9–3.9), 0.08 | 1.8 (0.9–3.25), 0.06 | 3.3 (1.7–6.5), 0.004* |
* P ≤ 0.05 significant, values in parenthesis are % frequencies, normal SGA category was taken as reference for comparison with other SGA categories by logistic regression