Table 1.

The different genotypic frequencies of the ten thrombophilic gene mutations in case and control groups

Mutation	Case (n = 89)			Control (n = 50)			P-valuea
	Normal (%)	Heterozygote (%)	Homozygote (%)	Normal (%)	Heterozygote (%)	Homozygote (%)
FV 1691G/Ab	97.75	2.25	0	100	0	0	0.536
FV HR2 4070 A/Gc	95.51	4.49	0	96	4	0	1.000
F II 20210 G/Ad	97.75	1.12	1.12	100	0	0	0.566
PAI-1 (-675 I/D, 5G/4G)e	29.21	55.05	15.73	30	56	14	0.963
ACE (intron 16 I/D)f	25.84	34.83	39.32	14	56	30	0.440
F VII (Gln353Arg)g	62.92	33.70	3.37	54	42	4	0.588
F XIII (Val34Leu)h	66.29	30.33	3.37	76	22	2	0.483
BF (-455G/A)i	50.56	42.69	6.74	48	48	4	0.718
G Ia (807C/T)j	31.46	56.17	12.35	36	38	26	0.056
tPA (intron 8 D/I)k	42.69	29.21	28.08	42	22	36	0.528

FV Factor V; FV HR2 Factor V-His1299 Arg; F II Factor II or Prothrombin; PAI-1 Plasminogen Activator Inhibitor-1; ACE Angiotansine Converting Enzume; F VII Factor VII; F XIII Factor XIII; BF beta fibrinogen; G Ia Glycoprotein Ia; tPA tissue Plasminogen Activator

^aEvaluated by Pearson’s chi-squared test

^bFV, at nucleotide position 1691 on the gene a G was exchanged by an A

^cFV HR2, at nucleotide position 4070 on the gene an A was exchanged by a G

^dF II, at nucleotide position 20210 on the gene a G was exchanged by an A

^ePAI-1, at nucleotide position -675 on the gene promoter a GGGG was exchanged by a GGGGG

^fACE, insertion/deletion of an Alu sequence of 287 bp in the intron 16 of the ACE gene

^gF VII, at codon position 353 of the protein was converted a Gln to an Arg

^hF XIII, at codon position 34 of the protein was converted a Val to a Leu

ⁱBF, at nucleotide position -455 on the gene promoter a G was exchanged by an A

^jG Ia, at nucleotide position 807 on the gene a C was exchanged by a T

^ktPA, Alu-repeat insertion/deletion (I/D) in intron 8 of the tPA gene