Table 2.
The frequencies of heterozygote and homozygote genotypes of the ten thrombophilic gene mutations in case and control groups
| Mutation | Frequencies of heterozygote genotype (%) | Frequencies of homozygote genotype (%) | ||||
|---|---|---|---|---|---|---|
| Case group | Control group | P-value | Case group | Control group | P-value | |
| FV 1691G/A | 2.25 | 0 | 0.536 | 0 | 0 | Not estimated |
| FV HR2 4070 A/G | 4.49 | 4 | 1.000 | 0 | 0 | Not estimated |
| F II 20210 G/A | 1.12 | 0 | 1.000 | 1.12 | 0 | 1.000 |
| PAI-1 (-675 I/D, 5G/4G) | 55.05 | 56 | 1.000 | 15.73 | 14 | 1.000 |
| ACE (intron 16 I/D) | 34.83 | 56 | 0.020 | 39.32 | 30 | 0.357 |
| Factor VII (Gln353Arg) | 33.70 | 42 | 0.363 | 3.37 | 4 | 1.000 |
| Factor XIII (Val34Leu) | 30.33 | 22 | 0.327 | 3.37 | 2 | 1.000 |
| BF (-455G/A) | 42.69 | 48 | 0.596 | 6.74 | 4 | 0.711 |
| G Ia (807C/T) | 56.17 | 38 | 0.052 | 12.35 | 26 | 0.060 |
| tPA (intron 8 D/I) | 29.21 | 22 | 0.426 | 28.80 | 36 | 0.346 |
| Total heterozygote genotypea | 28.98 | 28.60 | 1.000 | _ | _ | _ |
| Total homozygote genotypeb | _ | _ | _ | 11.01 | 11.60 | 1.000 |
FV Factor V; FV HR2 Factor V-His1299 Arg; F II Factor II or Prothrombin; PAI-1 Plasminogen Activator Inhibitor-1; ACE Angiotansine Converting Enzume; F VII Factor VII; F XIII Factor XIII; BF beta fibrinogen; G Ia Glycoprotein Ia; tPA tissue Plasminogen Activator
aThe frequencies of total heterozygote genotypes for all studied gene mutations
bThe frequencies of total homozygote genotypes for all studied gene mutations