The performances of the top eight features evaluated by using accuracy, Pearson correlation, and t test. The first four features (Ellipse_a/b, Ellipse_theta, Ep/Tp, and Ellipse_b) achieved better accuracy and Pearson correlation value than the last four. Ellipse_a/b, Ellipse_theta, Ep/Tp, and Ellipse_b were extracted from the best-fit ellipse. Tumor_p was the tumor perimeter. EPc was the contrast value of tumor. NRL_entropy was the regularity measurement of tumor boundary. Undulation described tumor margin