Table 1.
Mechanisms behind interaction between polymeric inhibitors and efflux pump.
| Sr. No. | Mechanism of interaction | Polymeric inhibitor |
|---|---|---|
| 1. | Bypass of drug efflux system by drug-polymer conjugate | Dendrimers⁎ |
| 2. | Inhibitors form conjugates with ATP that results into ATP depletion | Poloxamer unimers[42], Myrj, Brij, Dendrimers⁎ |
| 3. | Inhibitors interfering with ATP-binding sites resulting into site depletion for ATP binding | TPGS 1000[69], Dendrimers⁎ |
| 4. | Blockage of trans-membrane situated drug binding sites by polymeric inhibitor | Thiomers[68] |
| 5. | Interactions between membrane and polymeric inhibitor that alters the integrity of membrane lipids | PEG, Thiomers, Pluronics[42], Myrj, Brij, Dendrimers⁎ |
⁎
Possibly by mentioned mechanism as exact mechanism is not clear.