Table 1.
Subjects' characteristics
| Young | Older | P value | |
|---|---|---|---|
| n | 12 | 12 | |
| Age (years) | 21 ± 1 | 75 ± 1* | <0.001 |
| Weight (kg) | 74.4 ± 2.2 | 78.4 ± 2.1 | 0.195 |
| BMI (kg m−2) | 22.1 ± 0.6 | 25.8 ± 0.7* | 0.001 |
| Systolic blood pressure (mmHg) | 121 ± 2 | 145 ± 5* | <0.001 |
| Diastolic blood pressure (mmHg) | 61 ± 3 | 71 ± 4 | 0.051 |
| Fat (% body weight) | 14.4 ± 0.7 | 23.2 ± 1.1* | <0.001 |
| ALM (% body weight) | 37.4 ± 0.8 | 30.8 ± 0.7* | <0.001 |
| SMMI (kg m−2) | 8.5 ± 0.2 | 7.9 ± 0.2* | 0.024 |
| Basal plasma glucose (mmol L−1) | 5.0 ± 0.1 | 5.4 ± 0.1* | 0.012 |
| Plasma glucose OGTT t = 120 min (mmol L−1) | 5.0 ± 0.3 | 6.0 ± 0.6 | 0.177 |
| Basal plasma insulin (mU L−1) | 18 ± 3 | 21 ± 2 | 0.357 |
| Plasma insulin OGTT t = 120 min (mU L−1) | 51 ± 11 | 94 ± 16* | 0.033 |
| HbA1c (%) | 5.1 ± 0.1 | 5.7 ± 0.1* | <0.001 |
| HOMA | 4.3 ± 0.5 | 5.1 ± 0.6 | 0.357 |
| OGIS (mL min m−1) | 417 ± 18 | 346 ± 16* | 0.010 |
Values represent means ± SEMs. Data were analyzed with an unpaired, two-tailed Student's t test
BMI body mass index, ALM appendicular lean mass, SMMI skeletal muscle mass index, OGTT oral glucose tolerance test, HbA 1c glycated hemoglobin, HOMA homeostasis model assessment, OGIS oral glucose insulin sensitivity
*Significantly different from Young group, P < 0.05 (unpaired t test)