TABLE 2.
Replication results with P < 0.10 and meta-analysis results of those SNPs
| UMN Study | UPitt study | Meta-analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | SNP | Position (hg19) | Ref allele | Allele freq | OR | Z | P value | Allele freq | OR | Z | P value | OR (95 % CI) | Z | P value |
| 2 | rs10497394 | 174,297,659 | G | 0.629 | 1.754 | 4.18 | 2.9 × 10−5 | 0.637 | 1.422 | 4.07 | 4.7 × 10−5 | 1.51 (1.3–1.7) | 5.66 | 1.52 × 10−8 |
| 5 | rs386057 | 685,748 | G | 0.447 | 1.733 | 4.33 | 1.5 × 10−5 | 0.585 | 1.193 | 2.01 | 0.045 | 1.35 (1.2–1.6) | 3.98 | 6.94 × 10−5 |
| 15 | rs10775247 | 90,126,121 | C | 0.570 | 0.573 | −4.00 | 6.3 × 10−5 | 0.460 | 0.861 | −1.78 | 0.075 | 0.77 (0.67–0.89) | −3.62 | 3.00 × 10−4 |
| 15 | rs1110060 | 90,190,048 | A | 0.551 | 0.510 | −4.91 | 9.1 × 10−7a | 0.409 | 0.856 | −1.80 | 0.072 | 0.74 (0.64–0.85) | −4.10 | 4.09 × 10−5 |
Information provided in this table relates to the reference allele; Z score listed for minor allele
aMost significant result from UMN Study GWAS