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. Author manuscript; available in PMC: 2014 Mar 7.
Published in final edited form as: Mol Cell. 2013 Mar 7;49(5):10.1016/j.molcel.2013.02.010. doi: 10.1016/j.molcel.2013.02.010

Figure 1. Parallels in Small RNA-Mediated Chromatin Effects.

Figure 1

DNA silencing or cleavage is initiated by the biogenesis of small RNAs from host-encoded precursors, which are then bound by effector proteins and lead to the transcriptional silencing or elimination of complementary sequences. Orthologs are indicated as follows: Dicers, green; RNA-dependent RNA polymerase complexes, blue; polymerases, brown; Ago clade Argonautes, yellow; Piwi clade Argonautes, purple; histone and DNA methyltransferases, orange; and chromodomain-containing proteins, gray. Epigenetic modifications are represented as follows: H3K9me, blue; H3K27me, orange; and DNA methylation, green. The targets of small RNA-mediated TGS in each organism are indicated in the right panels.