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. Author manuscript; available in PMC: 2013 Nov 12.
Published in final edited form as: J Thromb Haemost. 2009 Aug 19;7(11):10.1111/j.1538-7836.2009.03594.x. doi: 10.1111/j.1538-7836.2009.03594.x

Figure 4.

Figure 4

Expressed wild-type and mutant recombinant VWF ELISA binding. (A) An ELISA-based binding assay using wild-type GPIb and added ristocetin shows lack of binding with the P1467S sequence variation compared to wild-type VWF. A control 2M mutation, Δ1392–1402, also shows lack of binding. (B) An ELISA-based binding assay using a gain-of-function GPIb in the absence of ristocetin shows normal binding for the P1467S construct, but lack of binding is again observed for the control 2M mutation, Δ1392–1402.