Table 3. Association of IL-6 and TNF-α Genotypes With Colorectal Adenomas.
| Gene | SNP | Alleles (m/M) | MAF cases | MAF controls | Caucasians Adjusted OR* (95% CI) | African Americans Adjusted OR* (95% CI) | All Subjects Adjusted OR** (95% CI) |
|---|---|---|---|---|---|---|---|
| IL-6 | rs2069840 | G/C | 0.23 | 0.27 | 0.89 (0.71 - 1.13) | 0.75 (0.50 - 1.11) | 0.86 (0.71 - 1.06) |
| IL-6 | rs1554606 | A/C | 0.39 | 0.39 | 1.08 (0.87 - 1.34) | 0.92 (0.69 - 1.23) | 1.01 (0.85 - 1.21) |
| IL-6 | rs2069827 | T/G | 0.05 | 0.06 | 0.86 (0.58 - 1.29) | 0.82 (0.28 - 2.40) | 0.84 (0.57 - 1.22) |
| IL-6 | rs2069849 | A/G | 0.08 | 0.07 | 1.47 (0.78 - 2.76) | 0.93 (0.64 - 1.35) | 1.05 (0.76 - 1.45) |
| TNF-α | rs3093662 | G/A | 0.07 | 0.07 | 1.15 (0.78 - 1.70) | 0.78 (0.45 - 1.34) | 0.99 (0.72 - 1.36) |
| TNF-α | rs1799964 | G/A | 0.18 | 0.18 | 1.05 (0.80 - 1.38) | 1.11 (0.77 - 1.61) | 1.06 (0.85 - 1.32 |
*
Odds ratios and 95% confidence intervals adjusted for age, sex, non-steroidal inflammatory drug use, BMI, family history of colorectal cancer, and smoking status. **In addition, adjusted for race.