Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Aug 21;23(21):10.1016/j.bmcl.2013.08.057. doi: 10.1016/j.bmcl.2013.08.057

Scheme 3.

Scheme 3

Synthesis of 15 and 16. Reagents and conditions: (a) 2-chloro-4-pyridylboronic acid, Na2CO3, PPh3, Pd2(dba)3, tol/EtOH/H2O (4:1:1), 105°C, o/n; (b) bis-(pinacolato)diborane, KOAc, PdCl2(dppf), dioxane, MW, 45 min, 145°C; (c) 2,4-dichloropyrimidine, Na2CO3, Pd2(dba)3, tol/EtOH/H2O (4:1:1), 105°C, o/n; (d) R1R2NH, DMF or NMP, heat.