Table 2.
Compound | R1 | R2 | X | TbrPDEB1 (% inh)a |
---|---|---|---|---|
11a | C | 34.0± 22.8 | ||
11b | C | 27.1 ± 6.1 | ||
12a | N | 15.8 ±21.2 | ||
12b | N | 29.8 ± 0.3 | ||
12c | N | 12.7 ± 17.9 | ||
12d | N | 20.6 ± 8.8 | ||
12e | N | 32.9 ± 6.0 | ||
12f | N | 3.9 ± 0.5 | ||
15a | C | 48.0 ± 3.1 | ||
15b | C | 28.4 ± 2.8 | ||
15c | C | 7.2 ± 33 | ||
16a | N | 14.5 ±20.5 | ||
16b | N | 16.1 ± 22.8 | ||
16c | N | 21.8 ± 4.6b | ||
16d | N | 23.2 ± 10.9 | ||
16e | N | 22.3 ± 11.2 | ||
16f | N | 18.5 ± 5.14 |
Data shown are average of 2 replicate independent experiments.
Replicate of 4 independent experiments.