Table 1.
Univariate predictors of intervention for re-coarctation by 12 months
| n | Overall (N=449) |
Re- coarctation (N=97) |
No Re- coarctation (N=452) |
HR | p | |
|---|---|---|---|---|---|---|
| Demographic Features | ||||||
| Gestational age (weeks) | 549 | 38.2 ± 1.6 | 38.1 ± 1.5 | 38.2 ± 1.6 | 0.96 | 0.56 |
| Birth weight (grams) | 549 | 3103 ± 541 | 3058 ± 478 | 3113 ± 554 | 1.0 | 0.14 |
| Age at Norwood (days) | 549 | 5.8 ± 4.1 | 4.8 ± 3.3 | 6.0 ± 4.2 | 0.94 | 0.08 |
| Race | 544 | 95 | 439 | 0.16 | ||
| White | 436 (80.2) | 80 (84.2) | 356 (81.1) | 0.95 | ||
| Black | 86 (15.8) | 13 (13.7) | 73 (16.6) | 0.88 | ||
| Asian | 10 (1.8) | 2 (2.1) | 8 (2.0) | Ref | ||
| Hispanic | 539 | 95 | 444 | 0.94 | 0.84 | |
| Yes | 101 (18.7) | 20 (21.3) | 81 (18.2) | |||
| Morphologic Features | ||||||
| HLHS subtype | 480 | 87 | 393 | 0.47 | ||
| Mitral atresia/Aortic atresia | 209 (43.5) | 42 (48.3) | 167 (42.5) | 1.43 | ||
| Mitral stenosis/Aortic atresia | 138 (28.8) | 19 (21.8) | 119 (30.3) | 1.16 | ||
| Mitral atresia/Aortic stenosis | 23 (4.8) | 6 (6.9) | 17 (4.3) | 1.92 | ||
| Mitral stenosis/Aortic stenosis | 110 (22.9) | 20 (23.0) | 90 (22.9) | Ref | ||
| Aortic atresia | 480 | 347 (72.3) | 61 (70.1) | 286 (72.8) | 1.02 | 0.47 |
| Native ascending aorta diameter | 527 | 97 | 430 | 0.59 | 0.03 | |
| > 2mm | 98 (18.6) | 24 (24.7) | 74 (17.2) | |||
| Surgical Variables | ||||||
| Bypass time (minutes) | 549 | 144 ± 54 | 137 ± 50 | 145 ± 55 | 1.0 | 0.65 |
| Coarctectomy | 548 | 96 | 452 | 1.1 | 0.63 | |
| Yes | 184 (33.6) | 30 (31.2) | 154 (34.1) | |||
| Shunt type (Intention to treat) | 549 | 97 | 452 | |||
| RV-PA shunt | 274 (49.9) | 56 (42.2) | 218 (48.3) | 1.2 | 0.32 | |
| MBTS | 275 (50.1) | 41 (57.8) | 234 (51.7) | Ref | ||
| Shunt type (actual shunt received) | 549 | 97 | 452 | |||
| RV-PA shunt | 281 (51.2) | 60 (61.9) | 221 (48.9) | 1.3 | 0.19 | |
| MBTS | 268 (48.8) | 37 (38.1) | 231 (51.1) | Ref | ||
| Echo Variables (Stage I Discharge) | ||||||
| Peak arch gradient (mm Hg) | 355 | 11.2 ± 7.9 | 14.9 ± 1.1 | 10.2 ± 6.5 | 1.06 | <0.01 |
| Distal arch diameter (mm) | 442 | 6.3 ± 1.5 | 5.9 ± 1.6 | 6.4 ± 1.5 | 0.18 | 0.04 |
| RV end-diastolic volume (mL/BSA1.3) | 309 | 93 ± 50 | 93 ± 32 | 93 ± 24 | 1.0 | 0.61 |
| RV end-systolic volume (mL/BSA1.3) | 309 | 50 ± 17 | 49 ± 21 | 50 ± 16 | 1.0 | 0.89 |
| RV fractional area change (%) | 376 | 37 ± 7 | 37 ± 8 | 37 ± 7 | 1.5 | 0.61 |
Data represent n ± 1 SD or n (%), HLHS represents Hypoplastic Left Heart Syndrome, RV represents right ventricle. Hazard ratios are from univariate Cox proportional hazards models.