Table 2.
Association of Candidate SNP Loci and Risk for Type 2 Diabetes Among Women and Men
| SNP | Loci | Major Allele (A) |
Minor Allele (a) |
Case Patients |
Control Participants |
Odds Ratio (95% CI)* |
P Value* | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF | AA/Aa/aa | MAF | AA/Aa/aa | AA | Aa | aa | Additive | |||||
| Women | ||||||||||||
| rs7923837 | HHEX | G† | A | 0.37 | 588/716/205 | 0.37 | 779/1000/263 | 1.00 | 0.90 (0.72–1.12) | 0.96 (0.76–1.21) | 1.01 (0.90–1.12) | 0.85 |
| rs1111875 | HHEX | G† | A | 0.40 | 571/782/237 | 0.40 | 724/1040/324 | 1.00 | 1.05 (0.85–1.29) | 1.11 (0.89–1.38) | 1.06 (0.95–1.17) | 0.31 |
| rs7756992 | CDKAL1 | A | G† | 0.31 | 739/716/124 | 0.28 | 1074/842/149 | 1.00 | 1.19 (1.03–1.39) | 1.31 (0.99–1.73) | 1.17 (1.04–1.31) | 0.007 |
| rs7754840 | CDKAL1 | G | C† | 0.32 | 718/705/157 | 0.30 | 1004/869/193 | 1.00 | 1.09 (0.94–1.26) | 1.19 (0.93–1.53) | 1.09 (0.98–1.22) | 0.10 |
| rs4402960 | IGF2BP2 | G | T† | 0.36 | 590/711/168 | 0.31 | 933/919/175 | 1.00 | 1.24 (1.06–1.45) | 1.60 (1.24–2.07) | 1.26 (1.12–1.40) | <0.001 |
| rs13266634 | SLC30A8 | C† | T | 0.27 | 838/633/115 | 0.30 | 1001/905/184 | 1.00 | 1.15 (0.87–1.51) | 1.38 (1.05–1.82) | 1.19 (1.06–1.33) | 0.003 |
| rs6446482 | WFS1 | G† | C | 0.38 | 601/738/237 | 0.40 | 716/1041/308 | 1.00 | 0.92 (0.75–1.14) | 1.09 (0.87–1.36) | 1.07 (0.97–1.19) | 0.190 |
| rs10010131 | WFS1 | G† | A | 0.37 | 614/731/222 | 0.40 | 728/1053/299 | 1.00 | 0.96 (0.76–1.18) | 1.14 (0.91–1.42) | 1.10 (0.99–1.22) | 0.090 |
| rs564398 | CDKN2B | A† | G | 0.40 | 573/733/255 | 0.42 | 694/1025/359 | 1.00 | 1.05 (0.86–1.29) | 1.22 (0.99–1.51) | 1.12 (1.01–1.24) | 0.040 |
| rs10811661 | CDKN2B | T† | C | 0.15 | 1137/416/34 | 0.18 | 1408/600/70 | 1.00 | 1.54 (0.97–2.45) | 1.66 (1.06–2.60) | 1.14 (1.00–1.31) | 0.050 |
| rs11037909 | EXT2 | T† | C | 0.27 | 835/639/104 | 0.27 | 1097/815/138 | 1.00 | 1.10 (0.82–1.49) | 1.00 (0.74–1.34) | 0.95 (0.85–1.07) | 0.39 |
| rs6698181 | PKN2 | C | T† | 0.39 | 598/748/243 | 0.37 | 837/939/314 | 1.00 | 1.09 (0.93–1.27) | 1.11 (0.89–1.37) | 1.06 (0.96–1.17) | 0.27 |
| rs17044137 | FLJ39370 | T | A† | 0.24 | 881/592/85 | 0.24 | 1191/769/117 | 1.00 | 1.02 (0.88–1.18) | 0.97 (0.70–1.34) | 1.00 (0.89–1.13) | 0.92 |
| rs7480010 | LOC387761 | A | G† | 0.28 | 813/636/124 | 0.28 | 1088/811/187 | 1.00 | 1.03 (0.89–1.20) | 0.86 (0.66–1.12) | 0.97 (0.87–1.08) | 0.53 |
| rs12255372 | TCF7L2 | G | T† | 0.33 | 715/666/182 | 0.27 | 1117/827/151 | 1.00 | 1.29 (1.11–1.50) | 2.00 (1.55–2.59) | 1.36 (1.22–1.52) | <0.001 |
| rs1801282 | PPARG | C† | G | 0.11 | 1252/319/18 | 0.13 | 1617/464/43 | 1.00 | 1.75 (0.96–3.21) | 1.98 (1.10–3.57) | 1.19 (1.02–1.39) | 0.030 |
| rs5219 | KCNJ11 | G | A† | 0.38 | 584/721/227 | 0.35 | 858/934/237 | 1.00 | 1.16 (0.99–1.35) | 1.36 (1.09–1.71) | 1.17 (1.05–1.30) | 0.007 |
| Men | ||||||||||||
| rs7923837 | HHEX | G† | A | 0.36 | 472/499/155 | 0.38 | 493/606/190 | 1.00 | 1.06 (0.81–1.37) | 1.31 (1.01–1.71) | 1.17 (1.03–1.32) | 0.010 |
| rs1111875 | HHEX | G† | A | 0.38 | 452/542/175 | 0.40 | 467/631/217 | 1.00 | 1.15 (0.90–1.47) | 1.41 (1.09–1.82) | 1.20 (1.06–1.35) | 0.003 |
| rs7756992 | CDKAL1 | A | G† | 0.35 | 452/522/131 | 0.28 | 657/520/94 | 1.00 | 1.48 (1.23–1.77) | 2.01 (1.48–2.74) | 1.44 (1.26–1.65) | <0.001 |
| rs7754840 | CDKAL1 | G | C† | 0.35 | 489/514/143 | 0.30 | 626/565/108 | 1.00 | 1.11 (0.92–1.32) | 1.62 (1.21–2.18) | 1.21 (1.06–1.38) | 0.004 |
| rs4402960 | IGF2BP2 | G | T† | 0.36 | 451/529/137 | 0.31 | 602/542/127 | 1.00 | 1.38 (1.15–1.65) | 1.47 (1.10–1.96) | 1.26 (1.11–1.44) | <0.001 |
| rs13266634 | SLC30A8 | C† | T | 0.26 | 629/449/76 | 0.31 | 613/571/123 | 1.00 | 1.54 (1.10–2.15) | 2.06 (1.48–2.88) | 1.39 (1.22–1.60) | <0.001 |
| rs6446482 | WFS1 | G† | C | 0.38 | 448/525/179 | 0.40 | 479/621/209 | 1.00 | 0.96 (0.75–1.23) | 1.04 (0.81–1.34) | 1.03 (0.91–1.16) | 0.75 |
| rs10010131 | WFS1 | G† | A | 0.37 | 449/535/160 | 0.40 | 471/616/201 | 1.00 | 1.07 (0.83–1.38) | 1.13 (0.87–1.47) | 1.06 (0.94–1.20) | 0.43 |
| rs564398 | CDKN2B | A† | G | 0.40 | 423/546/185 | 0.41 | 455/634/211 | 1.00 | 0.98 (0.77–1.25) | 1.11 (0.86–1.43) | 1.07 (0.95–1.21) | 0.30 |
| rs10811661 | CDKN2B | T† | C | 0.15 | 826/304/24 | 0.17 | 882/393/29 | 1.00 | 0.87 (0.48–1.58) | 1.11 (0.62–1.99) | 1.21 (1.03–1.43) | 0.030 |
| rs11037909 | EXT2 | T† | C | 0.24 | 664/413/72 | 0.27 | 700/515/95 | 1.00 | 0.95 (0.67–1.36) | 1.12 (0.79–1.58) | 1.11 (0.97–1.27) | 0.140 |
| rs6698181 | PKN2 | C | T† | 0.36 | 478/505/160 | 0.36 | 539/594/179 | 1.00 | 0.97 (0.81–1.16) | 0.96 (0.74–1.24) | 0.97 (0.86–1.10) | 0.75 |
| rs17044137 | FLJ39370 | T | A† | 0.29 | 515/556/51 | 0.27 | 651/574/67 | 1.00 | 1.29 (1.08–1.53) | 0.97 (0.64–1.43) | 1.15 (1.00–1.33) | 0.140 |
| rs7480010 | LOC387761 | A | G† | 0.29 | 583/469/106 | 0.30 | 639/549/117 | 1.00 | 0.92 (0.77–1.09) | 0.96 (0.71–1.30) | 0.95 (0.84–1.09) | 0.46 |
| rs12255372 | TCF7L2 | G | T† | 0.34 | 493/542/128 | 0.28 | 671/533/92 | 1.00 | 1.52 (1.27–1.82) | 2.08 (1.52–2.84) | 1.48 (1.29–1.69) | <0.001 |
| rs1801282 | PPARG | C† | G | 0.10 | 930/206/11 | 0.11 | 1039/260/19 | 1.00 | 2.28 (0.97–5.32) | 2.41 (1.05–5.55) | 1.15 (0.95–1.40) | 0.160 |
| rs5219 | KCNJ11 | G | A† | 0.36 | 471/554/152 | 0.37 | 524/602/189 | 1.00 | 1.06 (0.88–1.27) | 0.92 (0.71–1.20) | 0.99 (0.87–1.11) | 0.84 |
MAF = minor allele frequency; SNP = single nucleotide polymorphism.
*
Models are adjusted for age and body mass index (5 categories); P values are for the additive model.
†
Risk allele.