Tab. 2.

Outcome according to volume subgroups (V1-4, using cut-off values of 15/70/130 ml)

			3-year survival rates
			LRC	DMFS	DFS	OAS
cT4		n (%)	%	%	%	%
V1	1–15 ml	15 (7 %)	81	93	83	90
V2	16–70 ml	108 (54 %)	53	90	50	72
V3	71–130 ml	62 (31 %)	47	70	39	58
V4	> 130 ml	16 (8 %)	15	41	10	18
P value			< 0.0001	< 0.0001	< 0.0001	< 0.0001

LRC locoregional control rate, DMFS distant metastasis-free survival rate, DFS disease-free survival rate, OS overall survival rate.