Table 4.
Group | p-values of the difference across vaccine groups (Day 60) | ||||
---|---|---|---|---|---|
M72/AS02D (10 μg) | M72/AS01E (10 μg) | M72/AS01E (20 μg) | M72/Saline (40 μg) | AS01B | |
M72/AS02D (10 μg) | − | 0.005 | 0.044 | 0.015 | <0.001 |
M72/AS01E (10 μg) | 0.005 | − | 0.18 | <0.001 | <0.001 |
M72/AS01E (20 μg) | 0.044 | 0.18 | − | <0.001 | <0.001 |
M72/AS01B (40 μg) | 0.033 | 0.31 | 0.68 | 0.002 | <0.001 |
M72/Saline (40 μg) | 0.015 | <0.001 | <0.001 | − | <0.001 |
Differences between CD4+ T-cell responses elicited by the candidate vaccines were evaluated using the Kruskal-Wallis test without correction for multiplicity. The shown p-values correspond to the pair-wise comparisons of CD4+ T-cell responses expressing at least 2 immune markers (among CD40L, IL-2, TNF-α and IFN-γ) at Day 60