Table 4.

Differences between the vaccine-induced frequencies of M72-specific CD4⁺ T cells expressing at least 2 immune markers at Day 60

Group	p-values of the difference across vaccine groups (Day 60)
	M72/AS02D (10 μg)	M72/AS01E (10 μg)	M72/AS01E (20 μg)	M72/Saline (40 μg)	AS01B
M72/AS02D (10 μg)	−	0.005	0.044	0.015	<0.001
M72/AS01E (10 μg)	0.005	−	0.18	<0.001	<0.001
M72/AS01E (20 μg)	0.044	0.18	−	<0.001	<0.001
M72/AS01B (40 μg)	0.033	0.31	0.68	0.002	<0.001
M72/Saline (40 μg)	0.015	<0.001	<0.001	−	<0.001

Differences between CD4⁺ T-cell responses elicited by the candidate vaccines were evaluated using the Kruskal-Wallis test without correction for multiplicity. The shown p-values correspond to the pair-wise comparisons of CD4⁺ T-cell responses expressing at least 2 immune markers (among CD40L, IL-2, TNF-α and IFN-γ) at Day 60