Table 3. Effect of SB203580 , PD980559, SP6000125 on P38, ERK1/2 and JNK phosphorylation and P-selectin expression induced by Thrombin.
RP | RP-PD | RP-SB | RP-SP | |
P-selectin µg/ml | 11.29±2.58 | 10.16±2.22 | 12.62±4.22 | 26.10±5.90 |
Phospho/total ERK(%) | 13.29±4.60 | 12.62±4.22 | ||
Phospho/total P38 (%) | 20.07±4.80 | 10.53±2.55 | ||
Phospho/total JNK (%) | 12.33±5.04 | 26.89±5.15 | ||
Data are shown as the means (SD), Significant P- Value < 0.05. RP: Resting Platelets, OP: Oxidized-LDL treated Platelets, TP: Thrombin treated Platelets. SB:SB203580 , PD=PD980559, SP=SP6000125. |