Median and interquartile range for luteinizing hormone (A), serum estradiol (B), and estrone (C) on the day that the gonadotropin-releasing hormone agonist leuprolide was administered in the midluteal phase (week 0) and all subsequent time points. Data are shown by hot flash group (frequent and persistent, n = 10; infrequent and persistent, n = 10; not persistent, n = 9).