Fig. 4.

No evidence of increased anxiety-like behavior on the elevated plus-maze 24 h following last sweet fat diet access in rats with binge-like intake history. Separate groups of rats were treated (i.p.) with vehicle, or the CB₁ antagonist SR147778, or given a food prime prior to being placed on the maze. For food priming, rats received 3 pellets of sweet fat diet (binge group) or an equivalent weight of standard chow (chow group). Data are expressed as M±SEM in panels. a, b) Neither percentage of time spent on the open arms nor percentage of entries into the open arms differed between chow and binge rats under vehicle conditions or following treatment with an anorectic dose of SR147778 in an attempt to “precipitate” withdrawal from the sweet fat diet. Food priming also did not alter open arm time or entries. c) Overall locomotor activity, as measured by total arm entries was enhanced in binge relative to chow rats following a food prime only. Differs from chow **p<0.01.